submit news    HOME | FEEDBACK  


- Bio/Medicine

- Chemicals

- Defense

- Drug Delivery

- Education

- Electronics

- Energy

- Events

- Grants

- Industry

- Investment

- Litigation

- Materials


- Nanofabrication

- Nanoparticles

- Nanotubes

- Optics

- Partnership

- Patent

- Products

- Quantum dots

- Research

- Smart Dust

- Software

- Browse by Month

- Current Shows

- Previous Shows

- Submit Events

Become A Nanotechwire Partner

FEI Company

Veeco Instruments

Nano Science and Technology Institute

National Nanotechnology Initiative

Nanotechnology at Zyvex

Want to see your Company or Organization listed above? Become A Nanotechwire Partner Today - click here


6/25/2006 10:29:07 AM
Sugar-Based Nanoparticles Have Potential to Deliver Proteins Orally

Nanotechnology-based drug delivery research has largely focused on developing nanoparticles for use with drugs that are poorly soluble in water with many notable successes. Now, a team of investigators at the University of Santiago de Compostela in Spain has used two different sugars to create a nanoparticle that can entrap water-soluble molecules such as proteins. The researchers believe that this nanoparticle could be used to create protein drug formulations that can be taken by mouth rather than by injection or inhalation. The results of this study were published in the journal Macromolecules.

Maria Alonso, Ph.D., and colleagues used the water-soluble sugar polymers, or polysaccharides, known as chitosan (CS) and glucomannan (GM) to create the new nanoparticles. Chitosan, obtained from insect shells, is used primarily as a plant growth enhancer, while glucomannan, a plant root product, is a soluble fiber used to treat constipation and high cholesterol. By varying the relative amounts of the two polysaccharides, the researchers were able to create stable nanoparticles that could efficiently entrap proteins. Additional experiments using different forms of glucomannan and a crosslinking agent provided data that should enable the fine-tuning of the release rates of proteins from the nanoparticles.

This work is described in a paper titled, “Formation of new glucomannan-chitosan nanoparticles and study of their ability to associate and deliver proteins.” An investigator from Cantabria Pharmaceuticals in Madrid, Spain, also participated in this study. An abstract of this paper is available at the journal’s website.

Other Headlines from NCI Alliance for Nanotechnology in Cancer ...
 - Tekmira and the National Cancer Institute Publish Promising Data Demonstrating the Anti-Tumor Activity of a Novel Cancer Target
 - NCI Awards $1.7 Million to Cancer Specialist at Children’s Hospital Los Angeles
 - Nanoparticles Enhance Detection of Circulating Tumor Cells
 - Hand-held NMR Instrument Yields Rapid Analysis of Human Tumors
 - Biodegradable Biopolymer Nanoparticles Hold Promise for Twin Attack on Breast Cancer

More Drug Delivery Headlines ...
 - Independent clinical study validates Nanologica’s new drug carrier material for oral usage
 - Scientists engineer nanoscale vaults to encapsulate 'nanodisks' for drug delivery
 - Yissum Presents Promising Pre-Clinical Results for Oral Delivery of the Anti-Cancer Drug Docetaxel Using a Novel Nanotechnology Approach
 - CEA-Leti and 7 Partners to Study Ways to Improve Treatment of Inflammatory Bowel Disease
 - World first: localized delivery of an anti-cancer drug by remote-controlled microcarriers

« Back To List »

- submit company
- submit news
- submit events
- advertise here

- More Events

Copyright © 2017 | Privacy Policy |