submit news    HOME | FEEDBACK  


« NAVIGATION »
NEWS

- Bio/Medicine

- Chemicals

- Defense

- Drug Delivery

- Education

- Electronics

- Energy

- Events

- Grants

- Industry

- Investment

- Litigation

- Materials

- MEMS

- Nanofabrication

- Nanoparticles

- Nanotubes

- Optics

- Partnership

- Patent

- Products

- Quantum dots

- Research

- Smart Dust

- Software
COMPANIES
EVENTS

- Browse by Month

- Current Shows

- Previous Shows

- Submit Events
FEEDBACK
ADVERTISE
LINK TO US

« PARTNERS »
Become A Nanotechwire Partner

FEI Company

Veeco Instruments

Nano Science and Technology Institute

National Nanotechnology Initiative

Nanotechnology at Zyvex

Want to see your Company or Organization listed above? Become A Nanotechwire Partner Today - click here
« NEWSLETTER »



« SEARCH »







1/15/2007 9:34:28 AM
Detecting Cell Death with Quantum Dots

By combining a quantum dot with a novel carrier of the magnetic resonance imaging (MRI) agent gadolinium, a team of investigators at the University of Maastricht, in The Netherlands, has developed a nanoparticle that can spot apoptosis, or programmed cell death, using both MRI and fluorescence imaging. Tests in animals showed that this nanoparticle can provide anatomical information using MRI and cellular level information using fluorescence imaging. Imaging programmed cell death in the body could provide an early indication that an antitumor therapy is indeed killing cancer cells.

Reporting its work in the journal Nano Letters, a research team headed by Dick Slaaf, Ph.D., Marc van Zandvoort, Ph.D., and Chris Reutelingsperger, Ph.D., first developed a biocompatible molecular structure capable of binding strongly to eight gadolinium atoms, and then linked multiple carriers to each fluorescent quantum dot. The investigators also attached one molecule of annexin A5, a molecule that binds to the surface of cells undergoing apoptosis. The resulting nanoparticle contained enough gadolinium atoms to produce a strong MRI signal that would be detectable even if only a few of the nanoparticles were able to bind to an apoptotic cell.

To test the imaging ability of this nanoparticle, the investigators added it to cells triggered to start apoptosis. During the initial stages of apoptosis, the researchers were able to detect small patches of green fluorescence on the cell membrane. As apoptosis continued, these green patches spread across the entire cell membrane.

MRI experiments showed that the nanoparticle produced an imaging signal that was approximately 40 times stronger than that produced by the gadolinium carrier alone. Subsequent imaging experiments were able to detect injury-induced apoptosis in mice.

This work is detailed in a paper titled, “Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots.” An investigator from the Technische Universiteit Endhoven, in The Netherlands, also participated in this study. This paper was published online in advance of print publication. An abstract is available at the journal’s website.

View abstract.

Other Headlines from NCI Alliance for Nanotechnology in Cancer ...
 - Tekmira and the National Cancer Institute Publish Promising Data Demonstrating the Anti-Tumor Activity of a Novel Cancer Target
 - NCI Awards $1.7 Million to Cancer Specialist at Children’s Hospital Los Angeles
 - Nanoparticles Enhance Detection of Circulating Tumor Cells
 - Hand-held NMR Instrument Yields Rapid Analysis of Human Tumors
 - Biodegradable Biopolymer Nanoparticles Hold Promise for Twin Attack on Breast Cancer

More Quantum dots Headlines ...
 - Nanostart-holding Nanosys Unlocks Full Colour LCD Viewing Experience with Nanotechnology
 - Pairing Quantum Dots with Fullerenes for Nanoscale Photovoltaics
 - New Kid on the Plasmonic Block: Berkeley Lab Researchers Find Plasmonic Resonances in Semiconductor Nanocrystals
 - Size Matters: Smaller Particles Could Make Solar Panels More Efficient
 - $2 million in Stimulus Funding Supports Purchase of Two Mass Spectrometers for Health and Environmental Research


« Back To List »

« GET LISTED »
- submit company
- submit news
- submit events
- advertise here

« EVENTS »
- More Events


Copyright © 2014 Nanotechwire.com | Privacy Policy |