JMAR Technologies, Inc., a leading developer of advanced laser, high resolution imaging and photonics technologies, has successfully hit the 50 nm resolution milestone targeted in the development of its compact soft X-ray Microscope.
JMAR’s compact soft X-ray Microscope (XRM) bridges the sizeable gap between optical microscopes, which are typically greater than 200 nm resolution, and transmission electron microscopes that resolve feature sizes as small as 0.1 nm. Key advantages of the XRM include the ability to provide not only 2D images, but full 3D topographic reconstructions of whole cells, without altering the cell structure by slicing. Additionally, soft X-rays provide natural contrast for cell imaging, eliminating the need for staining. This greatly reduces sample preparation time and complexity, as compared to transmission electron microscopy, while still providing high resolution imaging.
“This is a significant milestone in the development of a commercially viable compact soft X-ray microscope. Researchers in the bio and life sciences will be able to do in their own labs what is currently only possible at a few large scale facilities worldwide,” said Dr. Oscar Hemberg, General Manager of JMAR’s Research Division. “We are very excited over our development progress and the potential for high-resolution, single-cell tomography.”
“Advances in nanotechnology, and more specifically soft X-ray microscopy, are paving the way for major breakthroughs in biomedical applications,” stated Neil Beer, CEO and president of JMAR. “JMAR’s expertise has positioned us on the cutting edge of these developing technologies.”
JMAR is completing its first working prototype of the XRM and there is active interest from several companies in partnering on the final development and commercialization of the instrument.