submit news    HOME | FEEDBACK  


« NAVIGATION »
NEWS

- Bio/Medicine

- Chemicals

- Defense

- Drug Delivery

- Education

- Electronics

- Energy

- Events

- Grants

- Industry

- Investment

- Litigation

- Materials

- MEMS

- Nanofabrication

- Nanoparticles

- Nanotubes

- Optics

- Partnership

- Patent

- Products

- Quantum dots

- Research

- Smart Dust

- Software
COMPANIES
EVENTS

- Browse by Month

- Current Shows

- Previous Shows

- Submit Events
FEEDBACK
ADVERTISE
LINK TO US

« PARTNERS »
Become A Nanotechwire Partner

FEI Company

Veeco Instruments

Nano Science and Technology Institute

National Nanotechnology Initiative

Nanotechnology at Zyvex

Want to see your Company or Organization listed above? Become A Nanotechwire Partner Today - click here
« NEWSLETTER »



« SEARCH »







10/7/2007 3:54:18 PM
Novel 3-D Cell Culture Model Shows Selective Tumor Uptake of Nanoparticles

A nanoparticle drug delivery system designed for brain tumor therapy has shown promising tumor cell selectivity in a novel cell culture model devised by University of Nottingham scientists. The results of this research, which was conducted by Martin Garnett, Ph.D., and colleagues, appear in the journal Experimental Biology and Medicine.

The nanoparticles used in this study were prepared from a novel biodegradable polymer poly(glycerol adipate). The polymer has been further modified to enhance incorporation of drugs and make the nanoparticles more effective.

To test the nanoparticles, the investigators developed a new in vitro system that should prove useful in a variety of brain cancer studies. "The interaction of tumor cells with brain cells varies between different tumors and different locations within the brain," explained Terence Parker, Ph.D., another investigator involved in this study. "Using three-dimensional culture models is therefore important in ensuring that the behavior of cells in culture is similar to that seen in real life."

Tumor cell aggregates have been used as cell culture models of cancer cells for many years. Similarly, thin brain slices from newborn rats can be cultured for weeks and are an important tool in brain biology. In the cell co-culture model now reported, these two techniques have been brought together for the first time. Brain tumor cell aggregates were labeled with fluorescent iron microparticles and grown on normal newborn rat brain tissue slices.

The double-cell labeling technique allowed investigation of tumor cell invasion into brain tissue by either fluorescence or electron microscopy from the same samples. Using these techniques, the tumor aggregates were found to invade the brain slices in a similar manner to tumors in the body.

This work is detailed in the paper, "Evaluation of poly(glycerol adipate) nanoparticle uptake in an in vitro 3-D brain tumor co-culture model." An abstract of this paper is available through PubMed.

View abstract.

Other Headlines from NCI Alliance for Nanotechnology in Cancer ...
 - Tekmira and the National Cancer Institute Publish Promising Data Demonstrating the Anti-Tumor Activity of a Novel Cancer Target
 - NCI Awards $1.7 Million to Cancer Specialist at Children’s Hospital Los Angeles
 - Nanoparticles Enhance Detection of Circulating Tumor Cells
 - Hand-held NMR Instrument Yields Rapid Analysis of Human Tumors
 - Biodegradable Biopolymer Nanoparticles Hold Promise for Twin Attack on Breast Cancer

Other Headlines from University of Nottingham ...
 - The University of Nottingham selects JPK´s innovative ForceRobot system for single molecule and biopharmaceutical applications
 - World-first to provide building blocks for new nano devices
 - Harnessing the potential of the oddly-shaped molecule
 - High definition diagnostic ultrasonics on the nanoscale
 - €1m to study the molecular chemistry of depleted Uranium

More Drug Delivery Headlines ...
 - Independent clinical study validates Nanologica’s new drug carrier material for oral usage
 - Scientists engineer nanoscale vaults to encapsulate 'nanodisks' for drug delivery
 - Yissum Presents Promising Pre-Clinical Results for Oral Delivery of the Anti-Cancer Drug Docetaxel Using a Novel Nanotechnology Approach
 - CEA-Leti and 7 Partners to Study Ways to Improve Treatment of Inflammatory Bowel Disease
 - World first: localized delivery of an anti-cancer drug by remote-controlled microcarriers


« Back To List »

« GET LISTED »
- submit company
- submit news
- submit events
- advertise here

« EVENTS »
- More Events


Copyright © 2014 Nanotechwire.com | Privacy Policy |