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Sunday, November 12, 2006 | Nanoparticles | 0 comments
Perfecting Targeted Nanoparticles for Anticancer Therapy
Though researchers have made substantial progress in developing drug-ferrying nanoparticles that successfully target tumor cells in living animals, including humans, investigators have only now started the detailed work needed to identify formulation parameters that would optimize drug delivery to malignant cells

Sunday, November 12, 2006 | Nanoparticles | 0 comments
Photodynamic Therapy with Nanoparticles Targets Tumors
Photodynamic therapy (PDT) uses a combination of ultraviolet or visible light and a light-sensitive chemical, or photosensitizer, to kill cancer cells using reactive oxygen.

Thursday, November 09, 2006 | Nanoparticles | 0 comments
Jefferson Researchers Find Nanoparticle Shows Promise in Reducing Radiation Side Effects
With the help of tiny, transparent zebrafish embryos, researchers at the Kimmel Cancer Center at Thomas Jefferson University and Jefferson Medical College are hoping to prove that a microscopic nanoparticle can be part of a “new class of radioprotective agents” that help protect normal tissue from radiation damage just as well as standard drugs.

Sunday, November 05, 2006 | Nanoparticles | 0 comments
Self-Assembling Nanoparticle Releases Drug Into Cell Cytoplasm
Researchers have developed a self-assembling nanoparticle that can sense the low pH of endosomes and fall apart. The disintegration of these nanoparticles not only releases their drug payload but enables it to exit the endosomes.

Sunday, November 05, 2006 | Nanoparticles | 0 comments
New Method Creates Porous, Multifunctional Silica Nanoparticles
Researchers have a new method for making silica nanoparticles that not only have carefully sized pores and are of a very narrow size distribution, but that are also magnetic and luminescent. The multiple functionality could enable investigators to create nanoparticles that can both image and treat tumors simultaneously

Saturday, October 28, 2006 | Nanoparticles | 0 comments
Versatile Self-Assembling Nanoparticles Improve Drug Potency
Nucleoside analogs such as cytarabine and gemcitabine are powerful anticancer agents, but a simple chemical modification that causes them to assemble into stable nanoparticles could make them even more valuable in the treatment of a wide variety of cancers.

Saturday, October 21, 2006 | Nanoparticles | 0 comments
Nanoparticles Deliver DNA-Drug Combos to Tumors
Efforts to treat cancer using genes and other oligonucleotides, such as short interfering RNA (siRNA), that turn off the biochemical processes that trigger malignancies have been hindered by difficulties in delivering nucleic acids to tumors. Nanoparticles hold promise for solving these issues.

Wednesday, October 11, 2006 | Nanoparticles | 0 comments
Nanoparticle Assembly Enters the Fast Lane
Method borrows instructions from molecular code of life

Sunday, October 08, 2006 | Nanoparticles | 0 comments
Temperature-Sensitive Nanoparticle Boosts Drug Antitumor Activity
Using temperature-sensitive, lipid- and polymer-based nanoparticles with a polymer coating, researchers in Korea have created an anticancer drug delivery vehicle that may provide a significant boost to the therapeutic efficacy of anticancer agents, particularly when used in conjunction with hyperthermia.

Sunday, October 08, 2006 | Nanoparticles | 0 comments
Study Outlines Key Parameters for Encapsulating Drugs in Nanoparticles
As a means of helping researchers develop nanoparticle-based formulations of water-insoluble drugs, investigators at the University of Texas at Austin have conducted a systematic study to quantify some of the key parameters involved in forming stable nanoparticles containing maximum levels of water-insoluble drug molecules.

Saturday, September 23, 2006 | Nanoparticles | 0 comments
Nanoparticles Boost Delivery of Cisplatin to Tumor Cells
Researchers have developed a nanoparticulate formulation of cisplatin that shows promise for overcoming drug resistance while boosting the amount of drug that accumulates inside malignant cells.

Saturday, September 16, 2006 | Nanoparticles | 0 comments
Coating Layered Nanoparticles Alters Immune Cell Uptake
Findings published in the journal Langmuir provide scientists with better information on how to design nanoparticles that avoid macrophage uptake.

Saturday, September 16, 2006 | Nanoparticles | 0 comments
New Methods for Screening Nanoparticles
Scientists at the Brookhaven National Laboratory have developed a screening method to examine how newly made nanoparticles interact with human cells following exposure for various times and doses.

Saturday, September 09, 2006 | Nanoparticles | 0 comments
Improving Magnetic Nanoparticle Design
Researchers are developing magnetic nanoparticles as miniature thermal scalpels for killing tumors as well as imaging them

Saturday, September 09, 2006 | Nanoparticles | 0 comments
Targeted Nanoparticles Aim to Improve Boron-Neutron Capture Therapy
Two recent papers in the journal Bioconjugate Chemistry suggest that targeted nanoparticles may be able to solve this problem.

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